Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.
Identifieur interne : 002066 ( Main/Exploration ); précédent : 002065; suivant : 002067Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.
Auteurs : B V Migunova ; A Z Plusnin ; N A Petrov ; M I Rivkin ; E B Grinbaum ; L V Obuchova ; O K KuznetzovSource :
- Acta virologica [ 0001-723X ] ; 1990.
Descripteurs français
- KwdFr :
- ADN viral (), Données de séquences moléculaires, Fréquence d'allèle, Glycoprotéine hémagglutinine du virus influenza, Gènes viraux, Humains, Hémagglutinines virales (génétique), Mutation, Orthomyxoviridae (génétique), Séquence d'acides aminés, Séquence nucléotidique, Variation des antigènes (génétique), Évolution biologique.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA, Viral.
- genetics : Antigenic Variation, Hemagglutinins, Viral, Orthomyxoviridae.
- Amino Acid Sequence, Base Sequence, Biological Evolution, Gene Frequency, Genes, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Molecular Sequence Data, Mutation.
Abstract
Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at position 51 of HA1 gene) caused an antigenic drift. One silent mutation was detected (nucleotide 428 of HA1 gene) which points at the relatedness of strains A/Leningrad/385/80 with A/Bangkok/2/79 and with other more recent strains. These data allowed to determine the position of the strain A/Leningrad/385/80 HA gene regarding to the evolutionary relationships of HA genes of influenza A (H3N2 subtype) viruses. The branch leading to the above-mentioned strain is supposed to start from a point common for strains isolated following A/Bangkok/1/79. The mutations of HA genes presented in this subgroup were analysed supporting the notion on limited evolutionary potential of the subtype H3N2 influenza viruses.
PubMed: 1980394
Affiliations:
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sort="Grinbaum, E B" uniqKey="Grinbaum E" first="E B" last="Grinbaum">E B Grinbaum</name></author><author><name sortKey="Obuchova, L V" sort="Obuchova, L V" uniqKey="Obuchova L" first="L V" last="Obuchova">L V Obuchova</name></author><author><name sortKey="Kuznetzov, O K" sort="Kuznetzov, O K" uniqKey="Kuznetzov O" first="O K" last="Kuznetzov">O K Kuznetzov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:1980394</idno><idno type="pmid">1980394</idno><idno type="wicri:Area/PubMed/Corpus">000453</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000453</idno><idno type="wicri:Area/PubMed/Curation">000453</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000453</idno><idno type="wicri:Area/PubMed/Checkpoint">000406</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000406</idno><idno 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biologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antigenic Variation</term><term>Hemagglutinins, Viral</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Orthomyxoviridae</term><term>Variation des antigènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Biological Evolution</term><term>Gene Frequency</term><term>Genes, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Données de séquences moléculaires</term><term>Fréquence d'allèle</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Gènes viraux</term><term>Humains</term><term>Mutation</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at position 51 of HA1 gene) caused an antigenic drift. One silent mutation was detected (nucleotide 428 of HA1 gene) which points at the relatedness of strains A/Leningrad/385/80 with A/Bangkok/2/79 and with other more recent strains. These data allowed to determine the position of the strain A/Leningrad/385/80 HA gene regarding to the evolutionary relationships of HA genes of influenza A (H3N2 subtype) viruses. The branch leading to the above-mentioned strain is supposed to start from a point common for strains isolated following A/Bangkok/1/79. The mutations of HA genes presented in this subgroup were analysed supporting the notion on limited evolutionary potential of the subtype H3N2 influenza viruses.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Grinbaum, E B" sort="Grinbaum, E B" uniqKey="Grinbaum E" first="E B" last="Grinbaum">E B Grinbaum</name><name sortKey="Kuznetzov, O K" sort="Kuznetzov, O K" uniqKey="Kuznetzov O" first="O K" last="Kuznetzov">O K Kuznetzov</name><name sortKey="Migunova, B V" sort="Migunova, B V" uniqKey="Migunova B" first="B V" last="Migunova">B V Migunova</name><name sortKey="Obuchova, L V" sort="Obuchova, L V" uniqKey="Obuchova L" first="L V" last="Obuchova">L V Obuchova</name><name sortKey="Petrov, N A" sort="Petrov, N A" uniqKey="Petrov N" first="N A" last="Petrov">N A Petrov</name><name sortKey="Plusnin, A Z" sort="Plusnin, A Z" uniqKey="Plusnin A" first="A Z" last="Plusnin">A Z Plusnin</name><name sortKey="Rivkin, M I" sort="Rivkin, M I" uniqKey="Rivkin M" first="M I" last="Rivkin">M I Rivkin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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